About The Bioactive Insight Series

Real Science. No Hype. Helping You Make Smarter Supplement Choices.

The Bioactive Insight is a consumer-focused podcast series dedicated to cutting through the noise and bringing you real, science-backed information about dietary supplements. In a world filled with marketing gimmicks and influencer hype, we provide evidence-based discussions to help you make informed decisions about your health.

💡Who It’s For: Supplement users who want clear, trustworthy information on what works, what doesn’t, and how to optimize their health through research-backed nutrition and wellness strategies.

🎙️What to Expect:

Easy-to-understand breakdowns of popular supplement ingredients.
Myth-busting and separating science from misinformation.
Expert insights on the best practices for supplement use.
Practical tips for diet, exercise, and lifestyle habits to complement your nutrition.

If you’re tired of confusing supplement advice, The Bioactive Insight delivers straight facts to help you take control of your health.

Episodes

S2 EP28 – Personalized Nutrition – From One-Size-Fits-All to True Precision | August 22, 2025

In this conversation, Dr. Bill Clark and Dr. Gene Bruno explore the evolving landscape of personalized nutrition, discussing its definition, the spectrum of personalization, and the implications of emerging technologies. They emphasize the importance of scientific rigor and consumer trust in the industry, while also addressing the potential of biohacking and true precision nutrition. The discussion highlights the need for innovation and evidence-based approaches to meet the growing demand for personalized wellness solutions.

S2 EP26 – Feeding the Brain – Nutraceuticals, Neuroplasticity & the Future of Cognitive Function | July 15, 2025

In this episode of The Bioactive Nexus podcast, Dr. Bill Clark and Dr. Gene Bruno delve into the critical topic of cognitive function, particularly as it relates to aging and the growing market for brain health supplements. They discuss the importance of understanding cognitive function's subdomains, such as memory and attention, and explore the mechanisms of action that underpin various nutraceuticals. The conversation highlights market trends, key ingredients for cognitive support, and the significance of formulation strategies that consider consumer expectations. The episode concludes with insights into future topics, including the role of psychedelics in cognitive health and the importance of gut health for brain function.

S2 EP24 - The 12 Hallmarks of Aging & Nutraceuticals | June 2, 2025

In this conversation, Dr. Gene Bruno and Dr. Bill Clark explore the twelve hallmarks of aging, discussing how each hallmark impacts health and longevity. They delve into the role of nutraceuticals in addressing these hallmarks, emphasizing the importance of genomic stability, telomere length, epigenetic alterations, and more. The discussion highlights the interconnectedness of these factors and their implications for maintaining health as we age.

S2 EP23 - Sexual Dysfunction & Supplements | April 29, 2025

In this episode, Dr. Gene and Dr. Bill discuss the multifaceted topic of sexual dysfunction and the role of various supplements in addressing it. They explore the prevalence of sexual dysfunction, the importance of a holistic approach that includes diet, exercise, and emotional health, and delve into specific supplements such as amino acids, botanicals, and hormones. The conversation highlights emerging research on ingredients like black ginger and the significance of using standardized, effective products for optimal results.

S2 EP22 - Healthy Aging | March 21, 2025

In this episode, Dr. Bill and Dr. Gene discuss the critical topic of healthy aging, exploring various aspects such as immune function, antioxidants, inflammation, and metabolic processes. They delve into the importance of dietary supplements and nutraceuticals in promoting longevity and overall wellness. The conversation highlights key ingredients like vitamin D, omega-3 fatty acids, curcumin, creatine, magnesium, and spermidine, emphasizing their roles in enhancing health as we age. The episode concludes with insights into emerging trends and future directions in the field of healthy aging.

S2 EP20 - Heart Health | February 14, 2025

In this episode of The Bioactive Insight, Dr. Gene and Dr. Bill celebrate Valentine's Day while discussing the importance of heart health. They delve into various nutraceuticals that can support cardiovascular health, including omega-3 fatty acids, antioxidants, turmeric, CoQ10, and more. The conversation also covers the role of diet, exercise, and stress management in maintaining heart health, emphasizing a comprehensive approach to wellness. Listener questions are addressed, providing insights into genetic predispositions and the benefits of magnesium and CoQ10.

S2 EP19 - NutriSelectAI Introduction | January 29, 2025

In this episode, Dr. Bill, Founder & CEO of NutriSelectAI, and Dr. Gene discuss the upcoming launch of NutriSelectAI, an innovative app designed to empower consumers in the dietary supplement industry. They explore the challenges consumers face, including misleading claims and the overwhelming number of products available. The conversation highlights the importance of transparency, scientific validation, and personalized recommendations in improving consumer trust and health outcomes. The hosts envision a future where NutriSelectAI transforms the industry by providing reliable information and fostering accountability among product brands.

Visit NutriSelectAI and presubscribe at: www.nutriselect.ai

S1 EP18 - End of Year Recap & What's Coming 2025 | December 20, 2024

In this episode, Dr. Bill and Dr. Gene reflect on the highlights of The Bioactive Nexus podcast throughout the year, discussing key themes such as AI's impact on the industry, the importance of magnesium and analytical testing, the microbiome revolution, and insights into women's and men's health. They also delve into diet myths, beauty from within, mandatory product listing, neurodivergents, botanical identity testing, and the emerging trends in biohacking. The conversation wraps up with a look ahead to future innovations and Dr. Bill's launch of Nutriselect.ai, an AI-powered app designed to guide consumers in making informed dietary supplement choices.

S1 EP13 - Demystifying Biohacking | September 30, 2024

This conversation explores the concept of biohacking, its origins, evolution, and various types, including DIY biology, nootropics, and genetic biohacking. The discussion highlights current trends in biohacking, such as the quantified self-movement and the use of technology for health optimization. Dr. Bill and Dr. Gene also delve into the future of biohacking, emphasizing the integration of AI, genetic editing, and wearable devices to enhance personal health and wellness.

S1 EP11 - Supplement Support for Neurodivergents | August 16, 2024

In this episode of The Bioactive Nexus, Dr. Bill and Dr. Gene explore the vital role of nutrition and supplementation in supporting neurodivergent conditions like autism, ADHD, and cerebellar hypoplasia. They share personal experiences with their neurodivergent children and discuss the benefits of nutrients such as magnesium, vitamin K2, folate, and omega-3 fatty acids for brain health. The conversation emphasizes the importance of individualized solutions and an integrative approach to improve cognitive function and overall well-being.

S1 EP9 - Beauty from Within | July 26, 2024

In this episode, Dr. Bill and Dr. Gene discuss exciting announcements, including the launch of Dr. Bill's new podcast "Where Spirit Meets Science" and Gene's upcoming book "The Vitamin Professor: A Guide to Real Science versus Marketing Science." They also share plans for live broadcasting at Supply Side West and their karaoke after-party. The main topic covers "beauty from within," focusing on supplements for skin, hair, and nails, highlighting ingredients like collagen, biotin, vitamin C, and more, along with the importance of combining topical and ingestible products for optimal results.

S1 EP8 - Why Take Supplements? | July 12, 2024

In this episode, Dr. Bill and Dr. Gene discuss the necessity of supplements in modern diets, debunking the myth that a good diet alone can meet all nutritional needs. They explore the benefits and limitations of various popular diets, including Mediterranean, keto, vegan, Paleo, and more, emphasizing the importance of individualization and consulting healthcare professionals. The conversation also highlights the significance of a healthy gut microbiome and the role of proper supplementation.