About The Bioactive Breakdown Series

Deep Dives into the Science Behind Supplements

The Bioactive Breakdown is our industry-focused podcast series that brings together leading experts, researchers, and innovators to explore the cutting-edge science behind dietary supplements. Each episode features a panel of three to four industry leaders, discussing the latest advancements in ingredient research, clinical studies, technology, and formulation innovations.

🔬Who It’s For: Professionals in the natural products industry, including R&D scientists, formulators, regulatory experts, and business leaders who want a data-driven, science-backed perspective on the evolving supplement landscape.

🎙️What to Expect:

Expert-led scientific discussions on bioactive ingredients.
Insights into clinical research, technology, and formulation breakthroughs.
Regulatory updates and best practices for product development.
Sponsorship opportunities for industry leaders to showcase their research. Please contact us for more information.

For those who live and breathe supplement science, this series is your go-to source for the latest in bioactive innovation.

Episodes

S2 EP21 - Hepatotoxicity in Dietary Supplements & Botanicals – Fact or Fiction? | February 28, 2025

In this deep dive conversation in The Bioactive Breakdown series, Dr. Bill, Dr. Gene and expert guests discuss the topic of hepatotoxicity in dietary supplements, particularly focusing on the implications of recent studies and media reports. They emphasize the importance of understanding the difference between correlation and causation, the challenges of self-reported dietary surveys, and the need for consumer awareness regarding supplement safety. The discussion also highlights the significance of clinical research in assessing liver health and the role of reputable brands in ensuring product safety and efficacy.

S1 EP18 - End of Year Recap & What's Coming 2025 | December 20, 2024

In this episode, Dr. Bill and Dr. Gene reflect on the highlights of The Bioactive Nexus podcast throughout the year, discussing key themes such as AI's impact on the industry, the importance of magnesium and analytical testing, the microbiome revolution, and insights into women's and men's health. They also delve into diet myths, beauty from within, mandatory product listing, neurodivergents, botanical identity testing, and the emerging trends in biohacking. The conversation wraps up with a look ahead to future innovations and Dr. Bill's launch of Nutriselect.ai, an AI-powered app designed to guide consumers in making informed dietary supplement choices.

S1 EP17 - The Science Revolution - The Bioactive Breakdown | November 22, 2024

In this next episode of The Bioactive Breakdown on The Bioactive Nexus podcast, Dr. Bill and Dr. Gene discuss the evolving landscape of dietary supplements, focusing on the importance of scientific research and consumer trust. They introduce their guests, who share insights on innovations in clinical research, the challenges posed by bad actors in the industry, and the role of technology in enhancing research methodologies. The conversation emphasizes the need for evidence-based practices and the significance of consumer education in building trust and credibility in the dietary supplement market. In this conversation, experts discuss the ongoing revolution in the dietary supplement industry, focusing on the need for scientific validation, consumer education, and the impact of bad actors. They explore future trends, including the role of AI in personalizing nutrition and the industry's shift towards evidence-based practices. The discussion emphasizes the importance of educating consumers to combat misinformation and the potential for a more sophisticated market driven by science and technology.

Please see the links below for more information on our guest's companies.

Radicle Science: https://radiclescience.com/

Reputable: https://www.reputable.health/

Alethios: https://alethios.com/

Center for Applied Health Sciences: https://thecahs.com/

S1 EP16 - SupplySide West Debrief | November 8, 2024

In this episode, hosts Dr. Gene and Dr. Bill recap their experiences at Supply Side West, discussing the diverse range of guests and insights gained from the event. They delve into the importance of relationships in the industry, the rising interest in peptides and GLP-1, and the need for regulatory frameworks. The conversation also covers trends in postbiotics, functional foods, and the shift towards data-driven decision making. They highlight innovations in delivery technologies and share personal highlights, including upcoming projects and a new book.

S1 EP15 - SupplySide West Perspectives - Industry Leaders | October 31, 2024

In this engaging conversation, industry leaders David Brown, Dr. Jacqueline Jacques, Dr. Jeff Chen, Thomas Aarts, Michael Anthonavage, Pelin Thorogood, and Danielle Lin, share their insights from SupplySide West 2024 in Las Vegas with Dr. Bill and Dr. Gene on the evolving landscape of health products, innovations in functional foods, and the importance of relationships within the industry. They discuss trends such as the rise of therapeutic peptides, the significance of clinical trials, and the future of dietary supplements, emphasizing the need for a proactive approach to regulations and consumer education.

S1 EP14 - Omega Fatty Acids - The Bioactive Breakdown | October 11, 2024

In this episode of The Bioactive Breakdown, Dr. Bill and Dr. Gene kick off the new series with an exploration of omega fatty acids. They discuss the different types, their health benefits, and the critical balance between omega-3 and omega-6 in the diet. Expert guests offer insights into krill oil and omega-7's role in metabolic health, while highlighting the growing market for omega-3s. The episode also emphasizes the importance of scientific research in understanding these nutrients and the innovations shaping their future in dietary supplements.

Please see the links below for more information on our guest's companies.

Aker BioMarine links:

1. https://www.superbakrill.com/

2. https://www.superbakrill.com/an-exploration-of-krill-marine-phospholipids

Tersus Life Sciences links:

1. https://tersuslifesciences.com/

2. https://www.brighamhealthonamission.org/2022/10/04/can-a-fatty-acid-supplement-improve-outcomes-in-obese-people-with-prediabetes/

3.https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1306528/full

Epax Norway links:

1. https://www.epax.com/products/epax-novuslipid

S1 EP12 - Botanical Identity Testing | September 9, 2024

Join us for a deep dive into the complexities of botanical identity testing in the latest episode of The Bioactive Nexus. Dr. Gene and Dr. Bill explore historical and modern testing methods, discuss the challenges of ensuring botanical authenticity, and highlight the importance of validated testing protocols. The episode also covers real-world case studies, illustrating the critical role of expertise in navigating the complexities of botanical testing.

See Dr. Bill's blog for more detailed info: https://natprologix.com/blog/f/a-review-of-testing-methodologies-for-botanical-identity-testing

S1 EP10 - Mandatory Product Listing | August 2, 2024

In this episode, Dr. Bill and Dr. Gene explore the topic of mandatory product listing (MPL) in the dietary supplement industry, highlighting both its benefits and challenges. They discuss the potential for MPL to enhance consumer safety, transparency, and regulatory oversight, while also addressing concerns about increased costs and regulatory burdens. The hosts emphasize the need for balanced legislation, adequate resources, and the involvement of an impartial group to draft effective MPL regulations.

S1 EP4 - How To Choose The Right CDMO Partner | May 3, 2024

In this episode, Dr. Bill and Dr. Gene discuss how to choose the right CDMO partner. They provide eight steps to follow in a methodical process, emphasizing the importance of defining requirements, researching potential CDMOs, evaluating capabilities and services, conducting due diligence, comparing proposals, negotiating contracts, initiating collaboration, and performing a GMP audit. They also highlight the significance of considering factors like scalability, supply chain management, and third-party certifications. They emphasize the importance of communication, risk mitigation, and monitoring and evaluating the process. The hosts share their experiences and offer valuable insights for selecting the right CDMO partner. The conversation provides valuable insights and tips for brand owners looking to work with a contract manufacturer.